Graphical Abstract

Abstract

Cellular organelles, such as the cytomembrane, lysosome, mitochondrion, Golgi apparatus, the endoplasmic reticulum, and nucleus, play important roles in the normal function of human cells. A comprehensive understanding of organelle-specific imaging can ultimately help us to design robust organelle-targeting therapeutic reagents for various underlying human diseases. Luminescent lanthanide molecular materials serve as an important and upcoming class of probes for cellular imaging applications with unique luminescent photophysical features such as sharp emission profiles from the visible to near-infrared spectral regions, long decay lifetimes, attractive quantum yields, large Stokes shifts, and a low propensity to photobleaching [1-3].  This talk focuses on recent advances in the design and development of organelle-targeting lanthanide molecular materials as well as their live-cell imaging applications [4,5].

Keywords

Organelle-targeting probes; lanthanide molecular materials; bioimaging; molecular engineering; recent advances.

References

1. S. S. Lekshmi, A. R. Ramya, M. L. P. Reddy, S. Varughese, Journal of Photochemistry Photobiology C: Photochemistry Reviews, 2017, 33, 109.
2. T. M. George, Mahesh S. Krishna and M. L. P. Reddy, Dalton Transactions, 2016, 45, 18719.
3. V. Divya and M. L. P. Reddy, Journal of Materials Chemistry C, 2013, 1,160.
4. D. B. Ambiliraj, Biju Francis and M. L. P. Reddy, Dalton Transactions, 2022, 51, 7748.
5. M.L.P. Reddy, K.S. Bejoymohandas, V. Divya, Dyes and Pigments, 2022, 205,110528.

Biography

MLP Reddy FAPASc, FISAS was educated from Sri Venkateswara University, Tirupathi, AP, India (1976-1984), where he obtained M.Sc., M.Phil., and Ph.D. degrees in Chemistry. He was appointed as a Scientist at Council of Scientific Industrial Research, National Institute for Interdisciplinary Science & Technology (NIIST-Thiruvananthapuram), rising to Chief Scientist in 2010, and served as a Head of the Division of Materials Science & Technology (2013-2016). His research interests are focused on Science, Technology and application of lanthanides with main emphasis on the development of lanthanide-based luminescent materials for OLEDs and bioimaging, Separation and purification of lanthanides, design of non-toxic NIR reflective pigments.

He has gained several national and international awards and prizes for his multidisciplinary research on Science, Technology of Rare Earths. 

• Elected Fellow of Andhra Pradesh Academy Sciences (2014) and honorary Fellow of Indian Society for Analytical Sciences (2022). 
• Recipient of bronze medal from Chemical Research Society of Indian in recognition of his scientific contributions in the field of rare earth chemistry.
• Receipt of Excellent Scientist Award from the Indian Society for Analytical Sciences towards his significant research contributions in the area of science and technology of rare earths for the year 2015.
• Received a Certificate of Membership award of American Chemical Society for the period 2015-2017.
• For the years 2019, 2020 and 2021, recognized as world 2% best scientists reported by Stanford University in the area of Inorganic and Nuclear Chemistry.
• Lifetime Achievement Award for the year 2021 by Rare Earth Association of India.

Research Accomplishments

• Published about 250 publications in peer reviewed International Journals of repute (ACS and RSC etc.)
• H-index = 52 as on June 2022 with 8000 citations.
• Several National and International Patents (US, France, Japan, Germany).
• 28 Ph.D students awarded doctorates in Chemistry by Kerala, Cochin, Utkal, Sri Venkateswara Universities and CSIR Academy.